Arthritis drugs tocilizumab and sarilumab lower deaths by Covid-19, says study

  • Outcomes were better when patients also received corticosteroids with the risk of dying 21 per cent compared to 25 per cent for those receiving usual care. This means that for every 100 such patients, four more will survive, the study said.
  • Arthritis drugs tocilizumab and sarilumab lower the risk of death and the need for ventilators among hospitalised Covid-19 patients, according to an analysis of nearly 11,000 patients.

    The study appeared in the Journal of the American Medical Association and prompted the World Health Organization (WHO) to recommend the use of the medicines, known as IL-6 inhibitors, in addition to corticosteroids among patients with severe or critical Covid, reports news agency AFP.

    Manu Shankar-Hari, a professor at King’s College London and lead author of the paper, told AFP that the research represented a “definitive piece of evidence” in favor of the drugs after earlier studies produced mixed results.

    The study said that among hospitalised Covid-19 patients, administering one of the drugs in addition to corticosteroids reduced the risk of death by 17 per cent, compared to the use of corticosteroids alone.

    In patients who were not on ventilators, the risk of progressing to mechanical ventilation or death was reduced by 21 per cent, compared to the use of corticosteroids alone. Severely ill Covid-19 patients experience an immune system overreaction known as a “cytokine storm” that can cause severe organ damage and death, the study noted.

    Tocilizumab and sarilumab are used to treat rheumatoid arthritis, an autoimmune condition, by inhibiting the effects of interleukin (IL)-6, a type of protein called a cytokine that signals the body to mount an inflammatory response.

    But previous research on whether IL-6 inhibitors can be useful against severe Covid-19 have variously reported benefit, no effect and harm. This prompted the WHO to coordinate the new study that combined data from 27 randomized trials conducted across 28 countries, the study said.

    The analysis included information on 10,930 patients, of whom 6,449 were randomly assigned to receive interleukin-6 inhibitors and 4,481 to receive usual care or placebo. Overall, the risk of Covid-19 death within 28 days was 22 per cent compared with an assumed risk of 25 per cent in those receiving only usual care.

    Outcomes were better when patients also received corticosteroids with the risk of dying 21 per cent compared to 25 per cent for those receiving usual care. This means that for every 100 such patients, four more will survive, the study said.

    The study also examined the impact of these drugs on whether patients progressed to ventilators or death. Among patients also given corticosteroids, the risk was found to be 26 percent for those receiving IL-6 inhibitors compared with an assumed 33 percent in those receiving usual care. For every 100 such patients, seven more will survive and avoid mechanical ventilation.

    Tocilizumab and sarilumab which are given by infusion or injection are currently recommended for use along with corticosteroids in severe Covid-19 patients by Britain. The United States also recommends tocilizumab with corticosteroids.

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